Mark Metzstein, Ph.D.

Associate Professor

Research Focus

My current focus is on education and mentoring of graduate students in biological sciences and in the preclinical curriculum of the Medical School. In the department, I am the Director of Graduate Studies and run the department journal clubs and research in progress talks. These forums are a key part of the cross department efforts to mentor and train our students in critical reading and presentation skills. I also teach an advanced genetics paper reading class, focussing on functional genomic analysis. In the medical school, I co-direct the preclinical Metabolism and Reproduction course. This course covers a large range of physiology, including the gastrointestinal system, the endocrine system, cell and body metabolism, and human reproductive biology and medicine. In addition, I work as a group facilitator for other courses throughout the medical school curriculum.

Representative Publications

Nelson JO, Moore KA, Chapin A, Hollien J, Metzstein MM. Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability. Elife. 2016 Mar 8;5:e12876. doi: 10.7554/eLife.12876. PMID: 26952209; PMCID: PMC4848089.

Nikolova LS, Metzstein MM. Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Development. 2015 Nov 15;142(22):3964-73. doi: 10.1242/dev.127902. Epub 2015 Oct 1. PMID: 26428009; PMCID: PMC6517834.

Jones TA, Nikolova LS, Schjelderup A, Metzstein MM. Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells. Dev Biol. 2014 Jun 1;390(1):41-50. doi: 10.1016/j.ydbio.2014.02.021. Epub 2014 Mar 4. PMID: 24607370; PMCID: PMC4041209.

Chapin A, Hu H, Rynearson SG, Hollien J, Yandell M, Metzstein MM. In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila. G3 (Bethesda). 2014 Mar 20;4(3):485-96. doi: 10.1534/g3.113.009357. PMID: 24429422; PMCID: PMC3962487.

Frizzell KA, Rynearson SG, Metzstein MM. Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. RNA. 2012 Aug;18(8):1475-86. doi: 10.1261/rna.032821.112. Epub 2012 Jun 27. PMID: 22740637; PMCID: PMC3404369.

Complete list at MyBibliography

Contact Information


Office: 801.493.5198


Building/Office: EIHG 6160A