Mario Capecchi, Ph.D.

Professor; H.A. and Edna Benning Presidential Endowed Chair

Research Focus





Representative Publications

Capecchi MR. The origin and evolution of gene targeting. Dev Biol. 2022 Jan;481:179-187. doi: 10.1016/j.ydbio.2021.10.007. Epub 2021 Oct 30. PMID: 34743970.

DeSalvo J, Ban Y, Li L, Sun X, Jiang Z, Kerr DA, Khanlari M, Boulina M, Capecchi MR, Partanen JM, Chen L, Kondo T, Ornitz DM, Trent JC, Eid JE. ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control. J Clin Invest. 2021 Jul 1;131(13):e141908. doi: 10.1172/JCI141908. PMID: 33983905; PMCID: PMC8245179.

Panza E, Ozenberger BB, Straessler KM, Barrott JJ, Li L, Wang Y, Xie M, Boulet A, Titen SW, Mason CC, Lazar AJ, Ding L, Capecchi MR, Jones KB. The clear cell sarcoma functional genomic landscape. J Clin Invest. 2021 Aug 2;131(15):e146301. doi: 10.1172/JCI146301. PMID: 34156976; PMCID: PMC8321568.

Titen S, Johnson M, Capecchi M, and Golic K (2020). Site-specific recombination with inverted target sites: a cautionary tale of dicentric and acentric chromosomes. Genetics Aug;215(4):923-930 PMID: 32586890

Nam HS and Capecchi MR (2020). Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life. Neural Dev. 17;15(1):3 PMID: 32183906

Wang H, Wu S, Capecchi M, and Jaenisch R (2020). A brief review of genome editing technology for generating animal models. Frontiers of Agricultural Science and Engineering 7:123-128 https://doi.org/10.15302/J-FASE-2019309

Tränkner D, Boulet A, Peden E, Focht R, Capecchi M (2019). A microglia sublineage protects from sex-linked anxiety symptoms and obsessive compulsion. Cell Reports 29(4):791-799 PMID: 31644903

Patel N, Wang J, Shiozawa K, Jones KB, Zhang Y, Prokop JW, Davenport GG, Nihira NT, Hao Z, Wong D, Brandsmeier L, Meadows SK, Sampaio AV, Werff RV, Endo M, Capecchi MR, McNagny KM, Mak TW, Nielsen TO, Underhill TM, Myers RM, Kondo T, Su L. (2019). HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression. iScience 13:43-54 PMID: 30818224

Yu D, Wang J, Zou H, Feng T, Chen L, Li J, Qi X, Li Z, Duan X, Xu C, Zhang L, Long X, Lan J, Chen C, Wang C, Xu X, Ren J, Zhao Y, Hu X, Lian Z, Men H, Pan D, Li N, Capecchi MR, Du X, Zhao Y, Wu S. (2018). Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning. Proc Natl Acad Sci USA PMID: 30381455

De, S., D. Van Deren, E. Peden, M. Hockin, A. Boulet, S. Titen and M. Capecchi (2018).  Two Distinct Ontogenies Confer Heterogeneity to Brain Microglia.  Development 145 PMID: 29973370.

Nagarajan N, Jones BW, West PJ, Marc RE, Capecchi MR. Corticostriatal circuit defects in Hoxb8 mutant mice. Mol Psychiatry. 2018 Sep;23(9):1868-1877. doi: 10.1038/mp.2017.180. Epub 2017 Sep 26. Erratum in: Mol Psychiatry. 2017 Nov 28;: PMID: 28948967; PMCID: PMC5970001.

Chen S.C., P. Tvrdik, E. Peden, S. Cho, S. Wu, G. Spangrude and M.R. Capecchi (2010).  Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice. Cell 141:775-785.  PMID: 20510925.

Complete list at MyBibliography

Personnel

Anne Boulet, Ph.D.
Anne Boulet, Ph.D.

Research Associate

Kayla Eschenbacher
Kayla Eschenbacher

Graduate Student

Kay M Higgins
Kay M Higgins

Laboratory Manager

Carol Lenz
Carol Lenz

Sr. Laboratory Specialist

Karl Lustig
Karl Lustig

Team Lead, Animal Care

Naveen Nagarajan, Ph.D.
Naveen Nagarajan, Ph.D.

Research Associate

Joan Shuhua
Joan Shuhua

Sr. Laboratory Specialist

Donn A. Van Deren, Ph.D.
Donn A. Van Deren, Ph.D.

Postdoctoral Fellow

Ben Xu, Ph.D.
Ben Xu, Ph.D.

Postdoctoral Fellow



Contact Information

Email: mario.capecchi@genetics.utah.edu

Office: 801.581.7096

Lab: 801.581.7096

Building/Office: EIHG 5440