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John F. Atkins, Ph.D., D.Sc.
Mario R. Capecchi, Ph.D.
Richard M. Cawthon, M.D., Ph.D.
Karen L. Eilbeck , Ph.D.
Raymond F. Gesteland, Ph.D.
David J. Grunwald, Ph.D.
Sandra J. Hasstedt, Ph.D.
Michael Howard, Ph.D .
Lynn B. Jorde, Ph.D.
Gabrielle Kardon, Ph.D.
Jean-Marc Lalouel, M.D., D.Sc..
Mark F. Leppert, Ph.D.
Anthea Letsou, Ph.D.
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Suzanne L. Mansour, Ph.D.
James E. Metherall, Ph.D.
Mark M. Metzstein , Ph.D.
L. Charles Murtaugh, Ph.D.
Andreas Rohrwasser, Ph.D.
Shigeru Sakonju, Ph.D.
Aloisia Schmid, Ph. D.
Gillian Stanfield, Ph.D.
Carl S. Thummel, Ph.D.
Robert B. Weiss ,Ph.D.
Qiang Wu, Ph.D.
Mark Yandell, Ph.D.
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John F. Atkins, Ph.D., D.Sc.
Research Professor
Lab Website
The exceptions to standard decoding provide us with insights that contribute to our understanding of standard decoding but they are also important in their own right. |  |
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Mario R. Capecchi, Ph.D.
Distinguished Professor and Co-Chairman
Lab Website
Since nearly all biological phenomena are mediated by genes, gene targeting is impacting the analysis of nearly all aspects of mammalian biology, including studies in cancer, development, immunology, neurobiology and human disease. |  |
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Richard M. Cawthon, M.D., Ph.D.
Research Associate Professor
According to some estimates, slowing the rate of aging just enough to postpone the age of onset of multiple age-related chronic diseases by two to three years would save hundreds of billions of dollars in health care costs. |  |
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Karen L. Eilbeck , Ph.D.
Research Assistant Professor
Lab Website
Bioinformatics is a branch of biological research that uses principles from mathematics and computer science to understand biological data. |
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Raymond F. Gesteland, Ph.D.
Distinguished Professor Vice President of Research Lab Website The newly described phenomenon of recoding is an essential mechanism for controlled gene expression and is used by all organisms. |  |
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David J. Grunwald, Ph.D.
Professor
The process by which the fertilized egg becomes a recognizable animal with many highly specialized and tightly organized cellular components has perplexed philosophers and scientists for millennia. |  |
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| Sandra J. Hasstedt, Ph.D.
Associate Professor
Lab Website
Understanding the inheritance of a disease and the disease genes location in the genome constitute the first steps in identifying a disease gene and, eventually, developing a treatment for the disease.
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Michael T. Howard , Ph.D.
Research Assistant Professor
The information contained within the human genome is decoded in a highly regulated and controlled manner. Recent research is revealing a level of hidden complexity in which RNA signals and trans-acting factors can alter conventional protein synthesis to control gene expression.
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| Lynn B. Jorde, Ph.D.
Professor
Lab Website
Limb malformation syndromes are a common group of disorders. Club foot alone is seen in approximately one in 1,000 births. |  |
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| Gabrielle Kardon, Ph.D.
Assistant Professor
Our research, using the chick and mouse model systems, is aimed at elucidating the genetic and molecular mechanisms and tissue interactions necessary for patterning and assembling the musculoskeleton during vertebrate development. |  |
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| Jean-Marc Lalouel, M.D., D.Sc.
Professor
Final elucidation of the process by which molecular variants of angiotensinogen predispose to hypertension should contribute to better diagnosis, treatment, and prevention of some forms of essential hypertension as well as certain complications of pregnancy. |  |
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Mark F. Leppert, Ph.D.
Distinguished Professor and Co-Chairman
Providing researchers throughout the worldwide genomic community with access to genetic markers and techniques for rapid, large-scale genotyping efforts will contribute to rapid advances in the identification of genes associated with diseases in humans. |  |
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Anthea Letsou, Ph.D.
Associate Professor
Our studies of Drosophila embryonic development provide a conceptual framework for studying mammalian developmental systems of cell-cell interaction such as neural tube closure. |  |
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Suzanne L. Mansour, Ph.D.
Associate Professor
We anticipate that some of the genes we identify will help us to understand how the ears sensory hair cells develop. |  |
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James E. Metherall, Ph.D.
Associate Professor
Lab Website
Heart disease accounts for more than 500,000 deaths each year in the United States. SLO disease is thought to cause mental retardation in more than 14,000 Americans. |  |
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Mark M. Metzstein , Ph.D.
Assistant Professor
Many organs, such as the lungs, the vasculature (blood system), and the kidneys, are composed of networks of cellular tubes.
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| L. Charles Murtaugh, Ph.D.
Assistant Professor
Although the pancreas is a relatively small organ, tucked away in a corner of the digestive tract, its diseases have a disproportionately large impact on humanity.
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Andreas Rohrwasser, Ph.D.
Research Assistant Professor
Our scientific interests are focused on volume dependent forms of hypertension, salt sensitivity, and the role of the kidney in these clinical conditions. |
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| Shigeru Sakonju, Ph.D.
Associate Professor
Many biological processes of the fruit fly are similar to those in higher organisms, including the mouse and humans.
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Aloisia Schmid, Ph. D.
Assistant Professor
Lab Website
Amyloidgenic diseases are diverse and include Alzheimer's Disease, Parkinson's Disease, Lou Gehrig's Disease (ALS), Huntington's Disease, amyloidosis, kidney diseases and a number of others.
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Gillian Stanfield, Ph.D.
Research Assistant Professor
Our studies of nematode reproduction focus on the signaling processes between sperm cells and their environment.
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Carl S. Thummel, Ph.D.
Professor
Lab Website
Although extensive evidence links steroid hormone receptors to cancer, the downstream steps by which abnormal receptor function leads to carcinogenesis are not yet defined. |  |
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Robert B. Weiss, Ph.D.
Professor
Lab Website
The flood of sequence information obtained through the Human Genome Project and the understanding and insight it brings to light will fundamentally change biology, medicine, and the biotechnology industry. |
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Qiang Wu, Ph.D.
Assistant Professor
Lab Website
Career Opportunity
A central problem in understanding brain development and function is determining how diverse neurons establish specific connections to form complex synaptic circuitry. |
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Mark Yandell , Ph.D.
AssociateProfessor
Bioinformatics is the science of creating, managing, and mining biological information as diverse as medical records, images, and sequence data.. |
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