Michael T. Howard, Ph.D.


The information contained within the human genome is decoded in a highly regulated and controlled manner. While the basic rules of decoding have been known for many decades, recent research is revealing a level of hidden complexity in which RNA signals and trans-acting factors can alter conventional protein synthesis to control gene expression. These findings have significant implications for our understanding of normal gene expression, and importantly, are providing insight into the molecular consequences of genetic mutations which lead to human disease.