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We use the zebrafish as an experimental system, working toward two broad research goals: to uncover conserved basic mechanisms that regulate the generation and organization of tissues in the vertebrate embryo and to understand the primary roles of molecular and genetic pathways that are disturbed in congenital birth defects.
Current research projects include:
1) the role of regulated calcium mobilization in muscle and neural disease and normal development;
2) transcription regulation of the pluripotent state of neural crest precursor cells; and
3) the mechanism be which T-box transcription factors interact to assign tissue identities in the early embryo.